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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Multi-omics analysis of tumor angiogenesis characteristics and potential epigenetic regulation mechanisms in renal clear cell carcinoma

Fig. 6

Differential methylation sites in two angiogenesis subgroups of TCGA KIRC patients. a Most differential methylation sites (70.14%) between Cluster_1 and Cluster_2 angiogenesis subgroups were presented as hypermethylation sites. Gene body and intergenic region shared the highest proportion of differential methylation sites; b, c GSEA analysis showed that those differential methylation sites were significantly enriched in tumor angiogenesis, VEGFA, immune, TP53 targets, and hypoxia-associated pathways; d, e higher CDH13 and RHOB expression in KIRC patients were associated with better OS according to Kaplan–Meier survival log-rank test; f, g, h Methylation levels of CDH13 related enhancer including cg00864293, cg03031932, and cg08344351 were negatively correlated with the expression level of CDH13; i, j, k Lower methylation levels of CDH13 related enhancer including cg00864293, cg03031932, and cg08344351 showed better OS

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Cell Communication and Signaling

ISSN: 1478-811X