Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning

Table 1 Modulation of Gpr55 mRNA levels by receptor ligands

Condition	Modulator	Gpr55 mRNA levels (fold non-differentiated)
w/o	–	1.0***
+ RANKL	–	16.1 ± 1.6
	+ 1 μM soybean LPI	24.5 ± 2.1**
	+ 0.5 μM ML-191	46.1 ± 5.1***
	+ 0.5 μM CBD	27.7 ± 0.5***
	+ 30 μM O1918	15.8 ± 3.1

RAW264.7 cells were treated without (w/o) or with 30 ng/mL RANKL for 72 h, in the absence or presence of the indicated GPR55 modulators
Data are means ± SEM of at least three independent experiments. **p < 0.01; ***p < 0.005 versus RANKL alone (one-way ANOVA, followed by Fisher’s least significant difference tests)
CBD cannabidiol

ISSN: 1478-811X