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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence

Fig. 5

Metastatic dissemination of ovarian cancer requires dynamic and reversible changes of plakin expression in the peritoneal microenvironment as the cancer progresses from primary tumour to floating multicellular spheroids and invasion onto peritoneal lining. The model includes potential involvement of DSP and PPL in STICs, the EMT process at (A) primary tumour, (B) multicellular aggregate form, (C) post-chemotherapy ascites-derived tumour cells and (D) tumour invasion of peritoneum and omentum sites where invading tumours trigger MMT and other changes in the surrounding mesothelium

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