Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions

Table 1 Pro-tumor and anti-tumor roles of TRIB2

Disease	Mechanism of action	Result	References
Pro-tumor
AML	Suppresses C/EBPα expression	Enhances AML progression	[50]
AML	Enhances the expression of anti-apoptotic BCL2	Enhances AML progression	[51]
CML	Stimulates the ERK pathway	Increases cell proliferation and drug resistance	[12]
T-ALL	Decreases C/EBPα expression	Promotes the growth and maintenance of T-ALL cells	[55]
Liver cancer	Increases YAP stabilization	Promotes cancer cell proliferation	[56]
Liver cancer	Interacts with PCBP2 and triggers the UPS	Reduces Ub flux and decrease the oxidative damage	[58]
Lung cancer	Decreases expression levels of C/EBPα	Accelerates cell proliferation and tumor growth	[59]
Malignant melanomas	Suppresses FOXO	Promotes cell proliferation, colony formation, maintenance, and progression	[63]
Human melanoma tissues and cell line		Migration and invasion	[64]
OS cell line		Enhances the malignant capacity	[10]
CRC	Suppresses p21 expression	Improves cell growth and progression, and block cellular senescence	[14]
GBM	Interacts with MAP3K1	Enhances resistance to chemotherapy and radiotherapy	[8]
Pancreatic cancer tissue	Suppresses the p53/MDM2 complex	Promotes resistance to anti-cancer therapy	[66]
LSCC	Interacts with XIST	Enhances proliferation and migration	[69]
OSCC	Interacts with TRIM	Facilitates the development of OSCC	[71]
Anti-tumor
Myeloid leukemia	Suppresses the Wnt pathway, stimulates activation of p38 stress signaling	Reduces cell propagation	[53]

AML acute myeloid leukemia, BCL2 B-cell lymphoma 2, CML chronic myelogenous leukemia, T-ALL T cell acute lymphoblastic leukemia, YAP yes-associated protein, FOXO Forkhead box protein O, OS osteosarcoma, CRC colorectal cancer, GBM glioblastoma; MAP3K1, MAP kinase kinase kinase 1, LSCC squamous cell carcinoma cells, XIST X inactivate-specific transcript, OSCC oral squamous cell carcinoma, TRIM tripartite motif, PCBP2 Poly (rC) binding protein 2, UPS Ubiquitin (Ub) proteasome system

ISSN: 1478-811X