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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells

Fig. 6

EGF-induced calcium release in MDA-NEO and MDA-HER2 cells is also impaired by PLD1 agonists. MDA-NEO cells and MDA-HER2 cells were pretreated with different concentrations of the PLD1 agonist PRE084 (a: MDA-NEO; b: MDA-HER2) or PPBP maleate (c: MDA-NEO; d: MDA-HER2) and then stimulated with 100 ng/ml EGF. The results are presented as the mean ± S.E.M. of three independent experiments. Statistical analysis: a–c One-way ANOVA and Tukey’s post hoc test: * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001. d One way ANOVA and Kruskal–Wallis post hoc test

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Cell Communication and Signaling

ISSN: 1478-811X