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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: The inhibitory effect of melatonin on human prostate cancer

Fig. 2

The MT1 pathway. (1) Melatonin up-regulated p27kip1 via blocking the activity of NF-κB. MT1 receptor activated Gαs and Gαq. Gαq directly activated PKC and Gαs indirectly activated PKA via elevating cAMP. PKC and PKA inhibited the binding ability of NF-κB to the promoter region of p27Kip1 gene. (2) Melatonin decreased the PSA level with an attenuated Ca2+ influx. Activated PKC inhibited the promoting effect of DHT and AR on KLK3 (PSA gene). MT1 receptor inhibited melatonin-responsive calmodulin to modulate L-type Ca2+ channel. (3) Melatonin interrupted the bi-directional positive interactions between AR-V7 and NF-κB. The MT 1 receptor-mediated inhibition on NF-κB decreased the formation of AR-V7 and thus blocking the interactions between AR-V7 and NF-κB

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