Fig. 2

Structural organisation of members of the human PPP family. The major isoforms are depicted schematically. PPPs share high homology in the amino-terminal part of the catalytic core domain, but the carboxy-terminal parts are less similar. Autoinhibitory regions (AI), Ca²⁺-binding EF-hands, tetratricopeptide repeats (TPR), putative nuclear localisation signals (NLS), Peptidyl-Prolyl-Isomerase like domain (PPI-like), calcineurin B and calmodulin (CaM) binding sites are indicated. The number of regulatory subunits of each phosphatases is given on the right