Fig. 2
From: Circadian clock: a regulator of the immunity in cancer
The protein clock BMAL1 heterodimerizes with CLOCK to initiate the transcription of targets genes through E-boxes. PER and CRY proteins inhibit the expression of BMAL1 and CLOCK, respectively, whereas RVE-ERBα/β does the opposite by binding to RREs. Additionally, CRY and PER are also negatively regulated by CK1ε/δ via phosphorylation