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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity

Fig. 8

Effects of CMTM7 knockdown on tumorigenicity and autophagy in vivo. A Representative images of nude mice (left) indicated the morphology of tumors derived from negative control cells and CMTM7 knockdown cells. The tumors were dissected and then were photographed (right). The growth curve (B) and average weight (C) of CMTM7 knockdown tumors versus the control tumors were expressed as means ± s.d. for each group (n = 4) (*P < 0.05). D Immunohistochemistry for Ki-67 of representative areas from CMTM7 knockdown tumor and control tumor. Scale bars: 50 µm. E Expression of Ki-67 was quantified by the percentage of Ki-67 positive cells to the total cells. Data are presented as means ± s.d. (**P < 0.01). F Transmission electron microscopy analysis of autophagosome- or autolysosome-like structures in the tumors of mice inoculated with control and CMTM7 knockdown A549 cells. G The number of autophagic vacuoles per cell was quantified and expressed as means ± s.d. of at least 20 cells (**P < 0.01)

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Cell Communication and Signaling

ISSN: 1478-811X