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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

Fig. 8

A schematic diagram showing the mechanisms associated with the increase of vimentin induced by HBX to facilitate hepatocarcinogenesis. HBX promotes vimentin expression in hepatoma cells to facilitate epithelial-mesenchymal transition, proliferation and migration, which is responsible for hepatocarcinogenesis. In addition, HBX could enhance vimentin expression through LASP1. On the one hand, multiple signal pathways, including PI3-K, EKR, and STAT3 are involved in the upregulation of vimentin mediated by LASP1 in HBX-positive hepatoma cells. On the other hand, HBX directly interacts with vimentin and LASP1, and dependent on LASP1, HBX could promote vimentin stability via protecting it from ubiquitination mediated protein degradation

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