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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

Fig. 7

LASP1 enhances proliferation and migration of HBX-positive hepatoma cells via vimentin. a The effect of vimentin on the proliferation of HBX-positive hepatoma cells mediated by LASP1 was detected with CCK-8 assays. b The effect of vimentin on the proliferation of HBX-positive hepatoma cells mediated by LASP1 was assessed with plate clone formation assays. c The effect of vimentin on the migration of HBX-positive hepatoma cells mediated by LASP1 was detected with transwell assays. d The effect of vimentin on the migration of HBX-positive hepatoma cells mediated by LASP1 was assessed with wound healing assays. Mock: cells transfected with control plasmid. HBX: cells transfected with HBX plasmid. HBX-shCON: HBX-positive cells transfected with shRNA control plasmid. HBX-shLASP1: HBX-positive cells transfected with shRNA plasmid targeting LASP1. HBX-shLASP1 + NC: HBX-positive with shRNA plasmid targeting LASP1 cells transfected with control expression plasmids of vimentin. HBX-shLASP1 + NC: HBX-positive with shRNA plasmids targeting LASP1 cells transfected with vimentin expression plasmids. *P < 0.05, the Mock group compared with the HBX group; #P < 0.05, the HBX-shCON group compared with the HBX-shLASP1 group. &P < 0.05, the HBX-shCON + NC group compared with the HBX-shLASP1 + VIM group

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