Skip to main content
Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

Fig. 4

The signal pathways involved in the regulation of vimentin expression mediated by LASP1 in HBX-positive hepatoma cells. a The inhibition of PI3-K, ERK, STAT3, and NF-kB pathways on vimentin expression in HBX-positive hepatoma cells. b The effect of over-expressed LASP1 on activation of PI3-K, ERK, and STAT3 pathways in HBX-positive hepatoma cells. c The inhibition of LASP1 on activation of PI3-K, ERK, and STAT3 pathways and the expression of vimentin in HBX-positive hepatoma cells. Mock: cells transfected with control plasmid. HBX: cells transfected with HBX plasmid. Flag-Mock: cells transfected with control expression plasmid with Flag tags. Flag-LASP1: cells transfected with LASP1 expression plasmid with Flag tags. HBX-shCON: HBX-positive cells transfected with shRNA control plasmid. HBX-shLASP1: HBX-positive cells transfected with shRNA plasmid targeting LASP1

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X