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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

Fig. 3

The effect of LASP1 on vimentin expression mediated by HBX in hepatoma cells. a The role of over-expressed LASP1 on the expressions of EMT markers, including vimentin, E-cadherin, and β-catenin in hepatoma cells. b The effect of HBX on the expression of LASP1 in hepatoma cells. c The inhibition of vimentin on the expression of LASP1 in HBX-positive hepatoma cells. d The inhibition of LASP1 mediated by specific shRNA in HBX-positive hepatoma cells. e The inhibition of LASP1 on the expression of vimentin, E-cadherin, and β-catenin in HBX-positive hepatoma cells. f The expression of LASP1 in HBV-related HCC tissues and associated adjacent tissues (× 400). g The correlation of LASP1 and vimentin protein expression in HBV-related HCC tissues (× 400). Flag-Mock: cells transfected with control expression plasmid with Flag tags. Flag-LASP1: cells transfected with LASP1 expression plasmid with Flag tags. Mock: cells transfected with control plasmid. HBX: cells transfected with HBX plasmid. shCON: cells transfected with shRNA control plasmid. shVIM: cells transfected with shRNA plasmid targeting vimentin. HBX-shCON: HBX-positive cells transfected with shRNA control plasmid. HBX-shLASP1: HBX-positive cells transfected with shRNA plasmid targeting LASP1. *P < 0.05

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Cell Communication and Signaling

ISSN: 1478-811X