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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

Fig. 2

HBX promotes the growth and migration of hepatoma cells through vimentin. a The effect of inhibition of vimentin expression using shRNA on the proliferation of HBX-positive hepatoma cells detected with CCK-8 assays. b The effect of inhibition of vimentin expression via shRNA on the proliferation of HBX-positive hepatoma cells assessed with plate clone formation assays. c The role of vimentin in the proliferation of hepatoma cells mediated by HBX in nude mice. d The effect of inhibition of vimentin expression via shRNA on the migration of HBX-positive hepatoma cells detected with transwell assays. e The effect of inhibition of vimentin expression using shRNA on the migration of HBX-positive hepatoma cells examined with wound healing assays. Mock: cells transfected with control plasmid. HBX: cells transfected with HBX plasmid. HBX-shCON: HBX-positive cells transfected with shRNA control plasmid. HBX-shVIM: HBX-positive cells transfected with shRNA plasmid targeting vimentin. In a, *P < 0.05, the Mock group compared with the HBX group; #P < 0.05, the HBX-shCON group compared with the HBX-shVIM group

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Cell Communication and Signaling

ISSN: 1478-811X