Fig. 3

Comparison of Ras effectors binding to RAS•GTP via its Ras binding domain (RBD) or via its RBD and additional membrane-associated domains. a Schematic representation of plasma membrane (PM), domain of RAS•GTP (in yellow) and example of an effector with three domains. The RBD of the effector that is used to bind Ras GTP is coloured in red. b Similar schematic representation as in (a), where the effector uses an additional domain (coloured in blue) for membrane association. In this example, the domain in blue represents an Src homology 2 (SH2) domain that can bind to a phosphorylated membrane receptor