Fig. 2

RAS-effector signaling pathways relevant in colon context. Effector proteins are grouped according to functional classes (see [13]). Effectors coloured in red indicate that a significant amount of effector (> 5%) is found in complex with RAS·GTP in normal colon context (based on computational models by Catozzi et al., in press). Effectors in blue indicate that context-dependent membrane recruitment of additional effectors present in effector pathways are needed in order to be significantly in complex with RAS GTP (see Catozzi et al., in press). Effectors are named following their official gene symbol