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Table 1 Modulation of CAF-related proteins in unirradiated AG1522 CAFs cocultured intimately with MDA-MB-231 cells relative to control AG1522 cells

From: Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity

Identified proteins

Function

Fold change (ambient atmosphere)

Fold change (hypoxic at in vivo‐like PO2)

Laminin subunit beta 1 (LAMB1)

Vascular basement membrane structure

3.8

4.0

High mobility group protein B1 (HMGB1)

Chromatin association nuclear protein

3.5

3.2

Caveolin‐1 OS = Homo sapiens (Cav‐1)

Integral membrane protein

0.65

0.36

Signal transducer and activator of transcription 1‐ alpha/beta (STAT1)

Cytoplasmic transcription factor

2.0

0.39

Insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3)

RNA binding factor

1.7

0.47

Actin, gamma‐enteric smooth muscle (ACTG2)

Cell migration

0.01

160

  1. Examples of proteins with documented association to CAF and/or cancer cells. These proteins were not between the ratio change thresholds of 0.68 and 1.5 and had spectral counts above 2 for all three triplicates from the mass spectra analysis