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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity

Fig. 6

Acquired radioresistance in CAFs cocultured with different cancer cell types. Induction of micronucleus formation in AG1522 CAFs cocultured for 120 h with MCF7 or MDA-MB-231 breast cancer cells, T98G glioblastoma cells, DU145 prostate carcinoma cells, or H1299 non-small cell lung cancer cells, and then irradiated with 1 Gy of 137Cs γ rays while in coculture. The fold change in micronuclei are normalized to respective sham-irradiated (0 Gy) controls. CAFs from each coculture showed significantly reduced levels of micronuclei, indicating an increased resistance to ionizing radiation, when compared to AG1522 control (p < 0.05). The results are representative of three separate experiments

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Cell Communication and Signaling

ISSN: 1478-811X