Fig. 8From: L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasivenessL-plastin Ser5 phosphorylation cascade in cancer cells. The ERK/MAPK and PI3K pathways are frequently dysregulated in cancer. Upon activation of these signalling pathways, their downstream effector kinases RSK1/2 and SGK3, respectively, are able to phosphorylate L-plastin on its residue Ser5. This phosphorylation leads to increased L-plastin bundling activity as well as enhanced recruitment to invadopodia and ECM degradation, promoting the invasiveness of the cancer cellBack to article page