TY - JOUR AU - Machado, Raquel A. C. AU - Stojevski, Dunja AU - De Landtsheer, Sébastien AU - Lucarelli, Philippe AU - Baron, Alexandre AU - Sauter, Thomas AU - Schaffner-Reckinger, Elisabeth PY - 2021 DA - 2021/02/22 TI - L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness JO - Cell Communication and Signaling SP - 22 VL - 19 IS - 1 AB - Metastasis is the predominant cause for cancer morbidity and mortality accounting for approximatively 90% of cancer deaths. The actin-bundling protein L-plastin has been proposed as a metastatic marker and phosphorylation on its residue Ser5 is known to increase its actin-bundling activity. We recently showed that activation of the ERK/MAPK signalling pathway leads to L-plastin Ser5 phosphorylation and that the downstream kinases RSK1 and RSK2 are able to directly phosphorylate Ser5. Here we investigate the involvement of the PI3K pathway in L-plastin Ser5 phosphorylation and the functional effect of this phosphorylation event in breast cancer cells. SN - 1478-811X UR - https://doi.org/10.1186/s12964-021-00710-5 DO - 10.1186/s12964-021-00710-5 ID - Machado2021 ER -