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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism

Fig. 5

Leucine transport rate as a function of leucine and arginine concentrations, and its effect on mTORC1 reactivation. Panel a, leucine transport rate is computed with arginine concentration taken to be 50 µM (“Starvation”), 175 µM (“Vehicle”), 375 µM (“ + 200 µM Arginine”), 575 µM (“ + 400 µM Arginine”). Data taken from [17]. Panel b, leucine transport rate shown for the full range of leucine and arginine concentrations. Predicted levels of mTORC1 pS2448 (c), activated ULK1 (d), and AMPK_pT172 (e) under amino acid depletion, obtained for differing arginine levels

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