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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism

Fig. 4

mTORC1 activity as a function of normalized leucine and sestrin2 concentrations, and model response to protein depletion and restoration. Panel a, mTORC1 activity for differing sestrin2 and leucine levels. Panel b, mTORC1 activity for the full range of leucine and sestrin2 concentrations. Predicted levels of mTORC1_pS2448 (c), p70S6K_pT389 (d), activated ULK1 (e), and AMPK_pT172 (f) under amino acid depletion (t < 120 min) and restoration (t > 120 min), obtained for differing sestrin2 levels

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Cell Communication and Signaling

ISSN: 1478-811X