Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression

Jin, Jing; Li, Yi; Zhao, Qijie; Chen, Yue; Fu, Shaozhi; Wu, JingBo

doi:10.1186/s12964-021-00705-2

Cell Communication and Signaling

Table 1 The role of STAT3 in regulating signaling proteins in immnue cells

From: Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression

Immune cells	Proteins	Relathionship with STAT3	References
MDSCs	IDO	MDSCs-activated STAT3 suppressed the T cell expansion and Th1 polarization via the IDO manner	[37]
	IRF-8	STAT3 downregulted the IRF-8 expression and promoted the MDSCs formation	[44]
	G-CSF	G-CSF mediated the STAT3/IRF-8 axis functions in MDSCs	[45]
	IL-6	IL-6 stimulated STAT3 phosphorylation in MDSCs	[48]
	S100A8/A9	STAT3 stimulated the S100A8/A9-mediated ROS, then suppressed CD4⁺ T cells accumulation	[59]
Macrophages	CD206/Arg-1/PTGS2	STAT3 inhibition suppressed these markers expression	[64, 73]
	HA	HA actived the STAT3 cascade	[72]
	A-FABP	A-FABP stimulated the STAT3 activation by promoting IL-6 production	[67]
	HIF-1α/TGF-β1	STAT3 upregulated HIF-1α/TGF-β1 expression, and influenced angiogenesis, tumor cells proliferation and metastasis	[82]
	PD-L1	STAT3 promoted the PD-L1 secretion on macrophages of tumor milieu	[87]
Dendritic Cells	PKCβII/PRKCB2	STAT3 reduce the PKCβII protein and PRKCB2 expression and suppressed DCs generation	[98]
	HER-2/neu	STAT3 inhibition downregulated the tumor surface HER-2/neu expression	[103]
	IL-10	IL-10-related signaling plays an important role in STAT3-elicited cDCs immunosuppressive response	[105]
	FLT3L	FLT3L promoted DCs proliferation via STAT3-dependent manners	[111]
	Tcf4	STAT3 interacted with Tcf4 promoters and increased the pDCs population	[110]
CD4 + T cells	IL-10	STAT3 increased the IL-10 expression and counteracted CD4 + T cells tumoricidal function	[34]
Tregs	Foxp3	STAT3 directly regulated the expression of Foxp3, and promoted the Tregs generation and immunosuppressive abilities	[138]
	IDO1	STAT3-mediated IDO1 expression increased the Foxp3⁺ Tregs in tumor milieu	[150]
CD8 + T cells	INF-α/β	STAT3-blocking induced INF-α/β production and triggered CD8⁺ T cells responses	[165, 167]
	GAPDH/HK2	STAT3 activation repressed GAPDH/HK2, which were critical glycolic indicators for T cells	[172, 174]
	FGFR4	Genetic instability of FGFR4 enhanced the STAT3 activation and possibly suppressed CD8⁺ T cells infiltration	[137]

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ISSN: 1478-811X

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