Fig. 9
From: Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
Dual effect of Baicalein on Tau. Tau in presence of heparin forms mature fibrils via intermediate oligomers formation. On the other hand, Tau in presence of Baicalein and heparin is restricted to form Tau oligomers without further mature fibril formation. These PHFs when exposed with Baicalein are dissolved into smaller fragments. The exposure of heparin-induced Tau oligomers and PHFs to healthy neuronal cells imparts toxicity in neurons and leads to neuronal death. The Baicalein-induced Tau oligomers as well as the dissolved fragments of PHFs do not affect the neuronal health and maintains the morphology. These suggest nontoxic nature of Baicalein-induced Tau oligomers