Fig. 6
From: Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
Dissolution of Tau aggregates by Baicalein. a The effect of Baicalein on the dissolution of mature Tau aggregates was studied using ThS fluorescence, which showed a decrease after 5 h of incubation in a concentration-dependent manner. b The percent disaggregation plot shows a maximum of 85% disaggregation by 500 μM of Baicalein treatment. c The plot shows the DC50 value for Tau disaggregation as 24.6 μM. d The CD analysis of disaggregated Tau by Baicalein shows the presence of mixed structures. The Sol. represents for soluble protein. (The statistical analysis was carried out by Student’s unpaired t test with respect to Baicalein untreated control. ***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05. ns non-significant p value). Further, post hoc analysis was carried by one-way ANOVA and Tukey’s criterion was determined for honestly significant difference (HSD). The data was considered significant if |X–X′|> Tukey’s criterion