Fig. 4
From: Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
Tau aggregation inhibition studied by CD spectroscopy. a The conformational analysis of Baicalein treated and control samples showed the typical spectra of a random coil structure. The Sol. represents soluble protein without heparin. b At the end of 120 h the pattern of spectrum remained same with respect to soluble (black arrow) and treated samples (pink arrow) showed a partial β-sheet conformation. c The control untreated sample shows the presence of long filaments (white arrows) at day 5. The treatment with 100 μM Baicalein at the initial time points showed presence of intermediately long filaments (white arrow) and small broken filaments. As the time advanced, Baicalein was shown to inhibit Tau aggregation as only broken pieces (highlighted by black border and black arrow) of Tau filaments were visualized in the electron micrographs