Fig. 2From: Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formationTau oligomerization-induced by Baicalein. a ANS fluorescence for aggregation kinetics of full-length Tau in presence of varying concentrations of Baicalein. b The highest concentration (500 μM) of Baicalein induced Tau oligomerization within 15 h of incubation as evidenced by sharp rise in ANS fluorescence. c The hydrophobicity changes at the end of 120 h revealed that 500 μM of Baicalein showed increased hydrophobicity which is characteristic property of oligomers. (The statistical analysis was carried out by Student’s unpaired t test with respect to Baicalein untreated control. ***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05. ns non-significant p value). Further, post hoc analysis was carried by one-way ANOVA and Tukey’s criterion was determined for honestly significant difference (HSD). The data was considered significant if |X–X′|> Tukey’s criterionBack to article page