Fig. 4
From: The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers
Bioinformatic analysis of the levels of transcripts of ATP6AP2 ((P) RR encoding gene) in various cancers, the possible cancer-related pathways that (P) RR may be involved in, as well as the correlation between (P) RR and corresponding pathway components, based on data in the TCGA and GTEx databases. a Levels of ATP6AP2 transcripts in tumor tissues of pancreatic adenocarcinoma (PAAD) and normal pancreatic tissues. ATP6AP2 expression is significantly higher in tumor tissues than that in normal tissues, moreover, level of ATP6AP2 expression in PAAD is positively correlated with the expression level of CTNNB1 (β-catenin encoding gene) and Wnt target gene AXIN2. b Levels of ATP6AP2 transcripts in tumor tissues of glioblastoma (GBM) and normal matched tissues. ATP6AP2 expression is higher in tumor tissues than that in normal tissues, moreover, level of ATP6AP2 expression in GBM is positively correlated with those of CTNNB1, CCND1 and AGT.c Levels of ATP6AP2 transcripts in tumor tissues of colon adenocarcinoma (COAD) and normal matched tissues. ATP6AP2 expression is higher in tumor tissues than that in normal tissues, moreover, level of ATP6AP2 transcripts in COAD is positively correlated with those of LRP6, CTNNB1, MYC, CCND1 and AXIN2.d Levels of ATP6AP2 transcripts in tumor tissues of breast invasive carcinoma (BRCA) and normal matched tissues. Level of ATP6AP2 transcripts in tumor tissues is obviously higher than that in normal tissues, moreover, level of ATP6AP2 expression in BRCA is positively correlated with those of the MAKP/ERK pathway components KRAS and BRAF, as well as that of the V-ATPase encoding gene ATP6V1C2.e Expression of ATP6AP2 in tumor tissues of uterine corpus endometrial carcinoma (UCEC) is at the similar level to that of the matched normal tissues. f Expression of ATP6AP2 in tumor tissues of either lung adenocarcinoma (LUAD) or lung squamous cell carcinoma (LUSC) are at similar levels to those of the corresponding normal tissues. TPM: transcripts per million; Correlation coefficient was analyzed via the Pearson-test