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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers

Fig. 2

Structure of (P)RR. The (pro) renin receptor ((P)RR) is a single transmembrane protein composed of an extracellular domain containing the N-terminal region, a transmembrane domain and a cytoplasmic domain containing the C-terminal region. The full-length (P) RR (FL(P)RR) protein can be cleaved by furin or ADAM19 into a truncated soluble form containing the N-terminal region (soluble (P)RR; s(P)RR) and a truncated transmembrane form containing the C-terminal region (M8–9 fragment)

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