Fig. 5
From: Tumor microenvironment complexity and therapeutic implications at a glance
A schematic representation of the exosome preparation. a-b, Exosomes derived either from the human lung cancer cell line A549 (A-Exo) with high EGFR expression or from the human lung fibroblast cell line HELF (H-Exo) with low EGFR expression. The isolated exosomes were further transfected with a DNA sequence coding for CD9 and CD63 markers. Synthesis and functionalization of MSN with EGFR-targeting aptamers. c, A-Exo is recognized and captured by MSN-AP in cell media and rat blood. d, MSN-AP eliminates circulating exosomes in animals and patient blood. Adapted from Springer Nature: Nature Communication, Copyright (2019) [188]