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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons

Fig. 4

Mitochondrial morphology and function in primary cortical neurons obtained from ncx3+/+ and ncx3−/− mice. (a-left), Imaging mitochondrial morphology in ncx3+/+ and ncx3−/− cortical neurons by confocal microscopy and MitoTracker Red (20 nM), N: neurons; scale bars: 10 μm. (a-right), quantification of the changes in mitochondrial morphology by Image J software. Form Factor (FF) and Aspect ratio (AR) in ncx3−/− neurons. b Confocal analysis of mitochondrial membrane potential and mitochondrial calcium concentration in ncx3+/+ and ncx3−/− cortical neurons. Each bar represents the mean + S.E.M. of the percentage of different experimental values obtained in three independent experimental sessions. *P < 0.05 vs ncx3+/+ and CTL; **P < 0.05 vs OGD

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Cell Communication and Signaling

ISSN: 1478-811X