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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons

Fig. 2

Mitochondrial function in primary cortical neurons obtained from siah2+/+ and siah2−/− mice exposed to OGD and OGD/Reoxygenation. Quantification of mitochondrial parameters in primary cortical neurons obtained from siah2+/+ and siah2−/− mice exposed to OGD and OGD followed by reoxygenation: a Mitochondrial calcium concentration, b Mitochondrial membrane potential, c Mitochondrial oxidative capacity and d ATP production. Each bar represents the mean + S.E.M. of the percentage values of at least 20–30 neurons recorded in three independent experimental sessions. *P < 0.05 vs siah2+/+ CTL; **P < 0.05 vs siah2+/+ OGD; ^P < 0.05 vs siah2+/+ OGD/Reoxy

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Cell Communication and Signaling

ISSN: 1478-811X