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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2

Fig. 3

eEF2K regulates c-Myc expression in a PKM2- and STAT3-depdendent manner. (A) A549 cells with or without eEF2K depletion were transfected with or without PKM2 depletion. Immunoblotting analyses were performed with the indicated antibodies (Aa). The relative expression levels of the indicated proteins were quantified (Ab). *P < 0.01, **P < 0.01, vs shNC. ##P < 0.01, vs sheEF2K. (B) A549 cells with or without eEF2K depletion or overexpression were treated with or without stattic. Immunoblotting analyses were performed with the indicated antibodies. (C) A549 cells with or without eEF2K depletion were transfected with or without STAT3 siRNA. Immunoblotting analyses were performed with the indicated antibodies

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