| Proposed Effects | Inhibitor | Cancer cell line tested | Refs |
---|---|---|---|---|
Signaling Pathways | Inhibiting IL-6/JAK/STAT3 pathway | Ilamycin C | MCF-7, MCF-10A | [34] |
bazedoxifene | SUM159, MDA-MB-231, MDA-MB-468 | [77] | ||
esculentoside A | MCF-7, MCF-10A, LO2 | [78] | ||
catechol | MCF-7, MDA-MB-231 | [79] | ||
scorpion venom | HCT-8, MDA-MB-231 | [80] | ||
dihydrotanshinone | MCF-7, MDA-MB-231 | [24] | ||
DT-13 | MDA-MB-231, MDA-MB-468 | [81] | ||
ganoderic acid A | MDA-MB-231 | [82] | ||
methylseleninic acid | 4 T1 | [83] | ||
sesquiterpenoid | MDA-MB-231 | [84] | ||
sabutoclax | MCF-7 | [85] | ||
tagalide A and tagalol A | MDA-MB-453, MDA- MB-231, SK-BR-3, MCF-7, MT-1, ZR-75-1 | [86] | ||
Inhibiting SIRT1/STAT3 pathway | I157172 | MCF-7 | [43] | |
Inhibiting miR-124/STAT3 pathway | cyanidin-3-glucoside | MDA-MB-231, Hs-578 T | [87] | |
Inhibiting EGFR/STAT3/Akt pathway | CAPE-pNO2 | MDA-MB-231 | [88] | |
Inhibiting STAT3/NF-κB pathway | metformin | MBCDF, MBCD3, MBCD4, MBCD17, MBCD23, MBCD25 | [89] | |
alantolactone | MDA-MB-231 | [90] | ||
Inhibiting STAT3/Nanong pathway | isoharringtonine | HCC1806, HCC1937, MCF-7 | [91] | |
Suppressing STAT3 function | Inhibiting STAT3 phosphorylation and dimerization | Galiellalactone SG-1709 SG-1721 | BT-549, BT-20, MDA–MB-468, MCF-7, T47D, SK-BR-3, MDA–MB-453 | [92] |
Inhibiting STAT3 phosphorylation/ activation | schisandrin A | MCF-7 | [93] | |
hexane fraction | MDA-MB-231 | [33] | ||
ruxolitinib | MCF-7 | [94] | ||
pyrimethamine | TUBO, TM40D-MB | [95] | ||
stattic | ZR-75-1 | [96] | ||
niclosamide | MCF-7, MDA-MB-231, MDA-MB-468 | [97] | ||
flubendazole | MDA-MB-231, Hs578T, BT-549, 4 T1 | [98] | ||
eupalinolide J | HEK 293, MDA-MB-468, MDA-MB-231 | [99] | ||
betulinic acid | MCF-7, MDA-MB-231 | [100] | ||
Direct binding to STAT3 | Binding to SH2 domain | cryptotanshinone KYZ3 | MDA-MB-231, MDA-MB-468, MCF-10A, L02 | [101] |
napabucasin | MDA-MB-231 | [102] | ||
coumarin-benzo [b] thiophene 1, 1-dioxide conjugates | MDA-MB-231, LO2, HepG2 | [103] | ||
Binding to Cys 259 and 251 sites | 15-keto PGE2 | MCF10A, MDA-MB-231, PC3 | [104] | |
Others | risedronate sodium and zoledronic acid | MCF-7, MDA-MB-231 | [105] | |
osthole | MDA-MB-231, BT-549, MDA-MB-468, MCF-7 | [106] |