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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I

Fig. 6

ME treatment changes STAT3, p70S6K, HKII and their associated pathways. a Receptor tyrosine kinase proteomic array of CAL 27 cells treated with HNK (20 μM), MGN (40 μM) or MHNK (20 μM). b Effects of HNK, MGN, MHNK, and ME on the phosphorylation status of STAT3 and p70S6K, and on the levels of HKII in CAL 27 cells. c-e ME treatment of oral tumors altered gene expression in the STAT3, p70S6K, and HKII pathways. f Pathway enrichment analysis identified the top 11 enriched pathways in ME-treated oral tumors vs. non-treated tumors, with STAT3, p70S6K and HKII pathways among the most enriched pathways

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