TY - JOUR AU - Rieke, D. T. AU - Klinghammer, K. AU - Keilholz, U. PY - 2016 DA - 2016// TI - Targeted therapy of head and neck Cancer JO - Oncol Res Treat VL - 39 UR - https://doi.org/10.1159/000452432 DO - 10.1159/000452432 ID - Rieke2016 ER - TY - JOUR AU - Pan, J. AU - Lee, Y. AU - Wang, Y. AU - You, M. PY - 2016 DA - 2016// TI - Honokiol targets mitochondria to halt cancer progression and metastasis JO - Mol Nutr Food Res VL - 60 UR - https://doi.org/10.1002/mnfr.201501007 DO - 10.1002/mnfr.201501007 ID - Pan2016 ER - TY - JOUR AU - Poivre, M. AU - Duez, P. PY - 2017 DA - 2017// TI - Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents JO - J Zhejiang Univ Sci B VL - 18 UR - https://doi.org/10.1631/jzus.B1600299 DO - 10.1631/jzus.B1600299 ID - Poivre2017 ER - TY - STD TI - Zhao X, Li F, Sun W, Gao L, Kim KS, Kim KT, Cai L, Zhang Z, Zheng Y. Extracts of Magnolia species-induced prevention of diabetic complications: a brief review. Int J Mol Sci. 2016;17:1629. https://doi.org/10.3390/ijms17101629. ID - ref4 ER - TY - JOUR AU - Lee, Y. J. AU - Lee, Y. M. AU - Lee, C. K. AU - Jung, J. K. AU - Han, S. B. AU - Hong, J. T. PY - 2011 DA - 2011// TI - Therapeutic applications of compounds in the Magnolia family JO - Pharmacol Ther VL - 130 UR - https://doi.org/10.1016/j.pharmthera.2011.01.010 DO - 10.1016/j.pharmthera.2011.01.010 ID - Lee2011 ER - TY - JOUR AU - Averett, C. AU - Arora, S. AU - Zubair, H. AU - Singh, S. AU - Bhardwaj, A. AU - Singh, A. P. PY - 2014 DA - 2014// TI - Molecular targets of Honokiol: a promising phytochemical for effective Cancer management JO - Enzymes VL - 36 UR - https://doi.org/10.1016/B978-0-12-802215-3.00009-4 DO - 10.1016/B978-0-12-802215-3.00009-4 ID - Averett2014 ER - TY - JOUR AU - Pan, J. AU - Zhang, Q. AU - Liu, Q. AU - Komas, S. M. AU - Kalyanaraman, B. AU - Lubet, R. A. AU - Wang, Y. AU - You, M. PY - 2014 DA - 2014// TI - Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function JO - Cancer Prev Res (Phila) VL - 7 UR - https://doi.org/10.1158/1940-6207.CAPR-14-0091 DO - 10.1158/1940-6207.CAPR-14-0091 ID - Pan2014 ER - TY - JOUR AU - Battle, T. E. AU - Arbiser, J. AU - Frank, D. A. PY - 2005 DA - 2005// TI - The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells JO - Blood VL - 106 UR - https://doi.org/10.1182/blood-2004-11-4273 DO - 10.1182/blood-2004-11-4273 ID - Battle2005 ER - TY - JOUR AU - Lin, C. J. AU - Chen, T. L. AU - Tseng, Y. Y. AU - Wu, G. J. AU - Hsieh, M. H. AU - Lin, Y. W. AU - Chen, R. M. PY - 2016 DA - 2016// TI - Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway JO - Toxicol Appl Pharmacol VL - 304 UR - https://doi.org/10.1016/j.taap.2016.05.018 DO - 10.1016/j.taap.2016.05.018 ID - Lin2016 ER - TY - JOUR AU - Leeman-Neill, R. J. AU - Cai, Q. AU - Joyce, S. C. AU - Thomas, S. M. AU - Bhola, N. E. AU - Neill, D. B. AU - Arbiser, J. L. AU - Grandis, J. R. PY - 2010 DA - 2010// TI - Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors JO - Clin Cancer Res VL - 16 UR - https://doi.org/10.1158/1078-0432.CCR-10-0333 DO - 10.1158/1078-0432.CCR-10-0333 ID - Leeman-Neill2010 ER - TY - JOUR AU - Banerjee, P. AU - Basu, A. AU - Arbiser, J. L. AU - Pal, S. PY - 2013 DA - 2013// TI - The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways JO - Cancer Lett VL - 338 UR - https://doi.org/10.1016/j.canlet.2013.05.036 DO - 10.1016/j.canlet.2013.05.036 ID - Banerjee2013 ER - TY - JOUR AU - Fong, W. F. AU - Tse, A. K. AU - Poon, K. H. AU - Wang, C. PY - 2005 DA - 2005// TI - Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid JO - Int J Biochem Cell Biol VL - 37 UR - https://doi.org/10.1016/j.biocel.2004.05.021 DO - 10.1016/j.biocel.2004.05.021 ID - Fong2005 ER - TY - JOUR AU - Lee, D. H. AU - Szczepanski, M. J. AU - Lee, Y. J. PY - 2009 DA - 2009// TI - Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells JO - J Cell Biochem VL - 106 UR - https://doi.org/10.1002/jcb.22098 DO - 10.1002/jcb.22098 ID - Lee2009 ER - TY - JOUR AU - Kang, Y. J. AU - Park, H. J. AU - Chung, H. J. AU - Min, H. Y. AU - Park, E. J. AU - Lee, M. A. AU - Shin, Y. AU - Lee, S. K. PY - 2012 DA - 2012// TI - Wnt/beta-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells JO - Mol Pharmacol VL - 82 UR - https://doi.org/10.1124/mol.112.078535 DO - 10.1124/mol.112.078535 ID - Kang2012 ER - TY - JOUR AU - Ou, H. C. AU - Chou, F. P. AU - Sheu, W. H. AU - Hsu, S. L. AU - Lee, W. J. PY - 2007 DA - 2007// TI - Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells JO - Arch Toxicol VL - 81 UR - https://doi.org/10.1007/s00204-006-0172-3 DO - 10.1007/s00204-006-0172-3 ID - Ou2007 ER - TY - JOUR AU - Chen, S. C. AU - Chang, Y. L. AU - Wang, D. L. AU - Cheng, J. J. PY - 2006 DA - 2006// TI - Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells JO - Br J Pharmacol VL - 148 UR - https://doi.org/10.1038/sj.bjp.0706647 DO - 10.1038/sj.bjp.0706647 ID - Chen2006 ER - TY - JOUR AU - Zhou, Y. AU - Bi, Y. AU - Yang, C. AU - Yang, J. AU - Jiang, Y. AU - Meng, F. AU - Yu, B. AU - Khan, M. AU - Ma, T. AU - Yang, H. PY - 2013 DA - 2013// TI - Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway JO - Pharmazie VL - 68 ID - Zhou2013 ER - TY - JOUR AU - Park, J. B. AU - Lee, M. S. AU - Cha, E. Y. AU - Lee, J. S. AU - Sul, J. Y. AU - Song, I. S. AU - Kim, J. Y. PY - 2012 DA - 2012// TI - Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway JO - Biol Pharm Bull VL - 35 UR - https://doi.org/10.1248/bpb.b12-00352 DO - 10.1248/bpb.b12-00352 ID - Park2012 ER - TY - JOUR AU - Cheng, Y. C. AU - Hueng, D. Y. AU - Huang, H. Y. AU - Chen, J. Y. AU - Chen, Y. PY - 2016 DA - 2016// TI - Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas JO - Oncotarget VL - 7 ID - Cheng2016 ER - TY - JOUR AU - Hyun, S. AU - Kim, M. S. AU - Song, Y. S. AU - Bak, Y. AU - Ham, S. Y. AU - Lee, D. H. AU - Hong, J. AU - Yoon, D. Y. PY - 2015 DA - 2015// TI - Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol induces apoptosis by triggering the intrinsic apoptosis pathway and inhibiting the PI3K/Akt survival pathway in SiHa human cervical cancer cells JO - J Microbiol Biotechnol VL - 25 UR - https://doi.org/10.4014/jmb.1411.11073 DO - 10.4014/jmb.1411.11073 ID - Hyun2015 ER - TY - JOUR AU - Lee, N. J. AU - Oh, J. H. AU - Ban, J. O. AU - Shim, J. H. AU - Lee, H. P. AU - Jung, J. K. AU - Ahn, B. W. AU - Yoon, D. Y. AU - Han, S. B. AU - Ham, Y. W. AU - Hong, J. T. PY - 2013 DA - 2013// TI - 4-O-methylhonokiol, a PPARgamma agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-kappaB activity JO - Br J Pharmacol VL - 168 UR - https://doi.org/10.1111/j.1476-5381.2012.02235.x DO - 10.1111/j.1476-5381.2012.02235.x ID - Lee2013 ER - TY - JOUR AU - Oh, J. H. AU - Ban, J. O. AU - Cho, M. C. AU - Jo, M. AU - Jung, J. K. AU - Ahn, B. AU - Yoon, D. Y. AU - Han, S. B. AU - Hong, J. T. PY - 2012 DA - 2012// TI - 4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-kappaB activity JO - J Nutr Biochem VL - 23 UR - https://doi.org/10.1016/j.jnutbio.2011.03.013 DO - 10.1016/j.jnutbio.2011.03.013 ID - Oh2012 ER - TY - JOUR AU - Xiao, S. AU - Chen, F. AU - Gao, C. PY - 2017 DA - 2017// TI - Antitumor activity of 4-O-Methylhonokiol in human oral cancer cells is mediated via ROS generation, disruption of mitochondrial potential, cell cycle arrest and modulation of Bcl-2/Bax proteins JO - J BUON VL - 22 ID - Xiao2017 ER - TY - JOUR AU - Bradford, M. M. PY - 1976 DA - 1976// TI - A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding JO - Anal Biochem VL - 72 UR - https://doi.org/10.1016/0003-2697(76)90527-3 DO - 10.1016/0003-2697(76)90527-3 ID - Bradford1976 ER - TY - JOUR AU - Cheng, G. AU - Zielonka, J. AU - Dranka, B. P. AU - McAllister, D. AU - Mackinnon, A. C. AU - Joseph, J. AU - Kalyanaraman, B. PY - 2012 DA - 2012// TI - Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death JO - Cancer Res VL - 72 UR - https://doi.org/10.1158/0008-5472.CAN-11-3928 DO - 10.1158/0008-5472.CAN-11-3928 ID - Cheng2012 ER - TY - JOUR AU - Cheng, G. AU - Zielonka, J. AU - McAllister, D. AU - Hardy, M. AU - Ouari, O. AU - Joseph, J. AU - Dwinell, M. B. AU - Kalyanaraman, B. PY - 2015 DA - 2015// TI - Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: role of mitochondrial bioenergetics and energy-sensing mechanism JO - Cancer Lett VL - 365 UR - https://doi.org/10.1016/j.canlet.2015.05.016 DO - 10.1016/j.canlet.2015.05.016 ID - Cheng2015 ER - TY - JOUR AU - Cheng, G. AU - Zielonka, J. AU - McAllister, D. AU - Tsai, S. AU - Dwinell, M. B. AU - Kalyanaraman, B. PY - 2014 DA - 2014// TI - Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation JO - Br J Cancer VL - 111 UR - https://doi.org/10.1038/bjc.2014.272 DO - 10.1038/bjc.2014.272 ID - Cheng2014 ER - TY - JOUR AU - Cheng, G. AU - Zielonka, J. AU - Ouari, O. AU - Lopez, M. AU - McAllister, D. AU - Boyle, K. AU - Barrios, C. S. AU - Weber, J. J. AU - Johnson, B. D. AU - Hardy, M. PY - 2016 DA - 2016// TI - Mitochondria-targeted analogues of metformin exhibit enhanced Antiproliferative and Radiosensitizing effects in pancreatic Cancer cells JO - Cancer Res VL - 76 UR - https://doi.org/10.1158/0008-5472.CAN-15-2534 DO - 10.1158/0008-5472.CAN-15-2534 ID - Cheng2016 ER - TY - JOUR AU - Myers, J. M. AU - Myers, C. R. PY - 2009 DA - 2009// TI - The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells JO - Free Radic Biol Med VL - 47 UR - https://doi.org/10.1016/j.freeradbiomed.2009.08.015 DO - 10.1016/j.freeradbiomed.2009.08.015 ID - Myers2009 ER - TY - JOUR AU - Myers, C. R. PY - 2016 DA - 2016// TI - Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase JO - Free Radic Biol Med VL - 91 UR - https://doi.org/10.1016/j.freeradbiomed.2015.12.008 DO - 10.1016/j.freeradbiomed.2015.12.008 ID - Myers2016 ER - TY - JOUR AU - Myers, C. R. AU - Antholine, W. E. AU - Myers, J. M. PY - 2010 DA - 2010// TI - The pro-oxidant chromium (VI) inhibits mitochondrial complex I, complex II, and aconitase in the bronchial epithelium: EPR markers for Fe-S proteins JO - Free Radic Biol Med VL - 49 UR - https://doi.org/10.1016/j.freeradbiomed.2010.09.020 DO - 10.1016/j.freeradbiomed.2010.09.020 ID - Myers2010 ER - TY - JOUR AU - Bennett, B. AU - Helbling, D. AU - Meng, H. AU - Jarzembowski, J. AU - Geurts, A. M. AU - Friederich, M. W. AU - Hove, J. L. K. AU - Lawlor, M. W. AU - Dimmock, D. P. PY - 2016 DA - 2016// TI - Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome JO - Free Radic Biol Med VL - 92 UR - https://doi.org/10.1016/j.freeradbiomed.2016.01.001 DO - 10.1016/j.freeradbiomed.2016.01.001 ID - Bennett2016 ER - TY - JOUR AU - Bauman, J. E. AU - Zang, Y. AU - Sen, M. AU - Li, C. AU - Wang, L. AU - Egner, P. A. AU - Fahey, J. W. AU - Normolle, D. P. AU - Grandis, J. R. AU - Kensler, T. W. AU - Johnson, D. E. PY - 2016 DA - 2016// TI - Prevention of carcinogen-induced Oral Cancer by Sulforaphane JO - Cancer Prev Res (Phila) VL - 9 UR - https://doi.org/10.1158/1940-6207.CAPR-15-0290 DO - 10.1158/1940-6207.CAPR-15-0290 ID - Bauman2016 ER - TY - JOUR AU - Wang, Y. AU - Yao, R. AU - Gao, S. AU - Wen, W. AU - Du, Y. AU - Szabo, E. AU - Hu, M. AU - Lubet, R. A. AU - You, M. PY - 2013 DA - 2013// TI - Chemopreventive effect of a mixture of Chinese herbs (antitumor B) on chemically induced oral carcinogenesis JO - Mol Carcinog VL - 52 UR - https://doi.org/10.1002/mc.20877 DO - 10.1002/mc.20877 ID - Wang2013 ER - TY - JOUR AU - Schoop, R. A. AU - Noteborn, M. H. AU - Baatenburg de Jong, R. J. PY - 2009 DA - 2009// TI - A mouse model for oral squamous cell carcinoma JO - J Mol Histol VL - 40 UR - https://doi.org/10.1007/s10735-009-9228-z DO - 10.1007/s10735-009-9228-z ID - Schoop2009 ER - TY - JOUR AU - Anders, S. AU - Pyl, P. T. AU - Huber, W. PY - 2015 DA - 2015// TI - HTSeq--a Python framework to work with high-throughput sequencing data JO - Bioinformatics VL - 31 UR - https://doi.org/10.1093/bioinformatics/btu638 DO - 10.1093/bioinformatics/btu638 ID - Anders2015 ER - TY - JOUR AU - Yu, J. N. AU - Meng, Q. Y. AU - Liu, W. J. AU - Lu, Y. L. AU - Ren, X. L. PY - 2014 DA - 2014// TI - Analysis of acidic endogenous phytohormones in grapes by using online solid-phase extraction coupled with LC-MS/MS JO - J Chromatogr Sci VL - 52 UR - https://doi.org/10.1093/chromsci/bmt162 DO - 10.1093/chromsci/bmt162 ID - Yu2014 ER - TY - JOUR AU - Cox, A. G. AU - Winterbourn, C. C. AU - Hampton, M. B. PY - 2009 DA - 2009// TI - Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling JO - Biochem J VL - 425 UR - https://doi.org/10.1042/BJ20091541 DO - 10.1042/BJ20091541 ID - Cox2009 ER - TY - JOUR AU - Sobotta, M. C. AU - Liou, W. AU - Stocker, S. AU - Talwar, D. AU - Oehler, M. AU - Ruppert, T. AU - Scharf, A. N. AU - Dick, T. P. PY - 2015 DA - 2015// TI - Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling JO - Nat Chem Biol VL - 11 UR - https://doi.org/10.1038/nchembio.1695 DO - 10.1038/nchembio.1695 ID - Sobotta2015 ER - TY - JOUR AU - Vazquez-Martin, A. AU - Cufi, S. AU - Oliveras-Ferraros, C. AU - Torres-Garcia, V. Z. AU - Corominas-Faja, B. AU - Cuyas, E. AU - Bonavia, R. AU - Visa, J. AU - Martin-Castillo, B. AU - Barrajon-Catalan, E. PY - 2013 DA - 2013// TI - IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations JO - Sci Rep VL - 3 UR - https://doi.org/10.1038/srep02560 DO - 10.1038/srep02560 ID - Vazquez-Martin2013 ER - TY - JOUR AU - Subramanian, A. AU - Tamayo, P. AU - Mootha, V. K. AU - Mukherjee, S. AU - Ebert, B. L. AU - Gillette, M. A. AU - Paulovich, A. AU - Pomeroy, S. L. AU - Golub, T. R. AU - Lander, E. S. AU - Mesirov, J. P. PY - 2005 DA - 2005// TI - Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles JO - Proc Natl Acad Sci U S A VL - 102 UR - https://doi.org/10.1073/pnas.0506580102 DO - 10.1073/pnas.0506580102 ID - Subramanian2005 ER - TY - JOUR AU - Sabharwal, S. S. AU - Schumacker, P. T. PY - 2014 DA - 2014// TI - Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel? JO - Nat Rev Cancer VL - 14 UR - https://doi.org/10.1038/nrc3803 DO - 10.1038/nrc3803 ID - Sabharwal2014 ER - TY - JOUR AU - Carling, D. PY - 2017 DA - 2017// TI - AMPK signalling in health and disease JO - Curr Opin Cell Biol VL - 45 UR - https://doi.org/10.1016/j.ceb.2017.01.005 DO - 10.1016/j.ceb.2017.01.005 ID - Carling2017 ER - TY - JOUR AU - Hardie, D. G. AU - Ashford, M. L. PY - 2014 DA - 2014// TI - AMPK: regulating energy balance at the cellular and whole body levels JO - Physiology (Bethesda) VL - 29 ID - Hardie2014 ER - TY - JOUR AU - Zmijewski, J. W. AU - Banerjee, S. AU - Bae, H. AU - Friggeri, A. AU - Lazarowski, E. R. AU - Abraham, E. PY - 2010 DA - 2010// TI - Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.143685 DO - 10.1074/jbc.M110.143685 ID - Zmijewski2010 ER - TY - JOUR AU - Poli, V. AU - Camporeale, A. PY - 2015 DA - 2015// TI - STAT3-mediated metabolic reprograming in cellular transformation and implications for drug resistance JO - Front Oncol VL - 5 UR - https://doi.org/10.3389/fonc.2015.00121 DO - 10.3389/fonc.2015.00121 ID - Poli2015 ER - TY - JOUR AU - Li, L. AU - Cheung, S. H. AU - Evans, E. L. AU - Shaw, P. E. PY - 2010 DA - 2010// TI - Modulation of gene expression and tumor cell growth by redox modification of STAT3 JO - Cancer Res VL - 70 UR - https://doi.org/10.1158/0008-5472.CAN-10-0894 DO - 10.1158/0008-5472.CAN-10-0894 ID - Li2010 ER - TY - JOUR AU - Shaw, P. E. PY - 2010 DA - 2010// TI - Could STAT3 provide a link between respiration and cell cycle progression? JO - Cell Cycle VL - 9 UR - https://doi.org/10.4161/cc.9.21.13677 DO - 10.4161/cc.9.21.13677 ID - Shaw2010 ER - TY - JOUR AU - Hoyer-Hansen, M. AU - Jaattela, M. PY - 2007 DA - 2007// TI - Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium JO - Cell Death Differ VL - 14 UR - https://doi.org/10.1038/sj.cdd.4402200 DO - 10.1038/sj.cdd.4402200 ID - Hoyer-Hansen2007 ER - TY - JOUR AU - Roberts, D. J. AU - Miyamoto, S. PY - 2015 DA - 2015// TI - Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy JO - Cell Death Differ VL - 22 UR - https://doi.org/10.1038/cdd.2014.173 DO - 10.1038/cdd.2014.173 ID - Roberts2015 ER - TY - JOUR AU - Collins, J. A. AU - Wood, S. T. AU - Nelson, K. J. AU - Rowe, M. A. AU - Carlson, C. S. AU - Chubinskaya, S. AU - Poole, L. B. AU - Furdui, C. M. AU - Loeser, R. F. PY - 2016 DA - 2016// TI - Oxidative stress promotes Peroxiredoxin Hyperoxidation and attenuates pro-survival signaling in aging chondrocytes JO - J Biol Chem VL - 291 UR - https://doi.org/10.1074/jbc.M115.693523 DO - 10.1074/jbc.M115.693523 ID - Collins2016 ER -