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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

Fig. 1

Both Wnt/β-catenin and RAS signaling pathways are activated in CRC harboring CSC properties. a, b GSEA of CRC patient tissues (GSE13294, N = 125; GSE14333, N = 246) of the (a) canonical Wnt and (b) RAS pathways in the stem-like subtype of CRC tumors (GSE13294, N = 20; GSE14333, N = 55) and other differentiated CRC tumors. c Immunoblot analyses of CRC cell lines comparing CSC-like (CSC) and non-CSC-like (non-CSC) populations of CRC cell lines using the indicated antibodies. CSC and non-CSC-like population of CRC cells were sorted by FACS using CD44, CD133, and CD166 antibodies

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Cell Communication and Signaling

ISSN: 1478-811X