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Table 4 Interactive analysis between rs11085996 within UCA1 and living habits on susceptibility to colorectal cancer

From: SNP rs12982687 affects binding capacity of lncRNA UCA1 with miR-873-5p: involvement in smoking-triggered colorectal cancer progression

Clinical feature

Genotype

Classifications

Case

Control

P value

OR (95% CI)

βe

βeg

γ value*

Age (years)

GG

<50

64

130

  

0.00

  

AG

<50

35

46

0.108

1.55 (0.91–2.63)

0.44

  

AA

<50

240

497

0.911

0.98 (0.70–1.37)

−0.02

  

GG

≥50

24

30

0.120

1.63 (0.88–3.00)

0.00

0.49

–

AG

≥50

118

257

0.712

0.93 (0.64–1.35)

0.44

−0.07

−0.16

AA

≥50

281

448

0.155

1.27 (0.91–1.78)

−0.02

0.24

−12.11

Gender

GG

Female

42

34

  

0.00

  

AG

Female

46

92

0.002

0.40 (0.23–0.72)

−0.90

  

AA

Female

101

175

0.003

0.47 (0.28–0.78)

−0.76

  

GG

Male

46

126

< 0.001

0.30 (0.17–0.52)

0.00

−1.22

–

AG

Male

107

211

< 0.001

0.41 (0.25–0.68)

−0.90

−0.89

1.00

AA

Male

420

770

< 0.001

0.44 (0.28–0.70)

−0.76

− 0.82

1.08

Smoking

GG

None

10

37

  

0.00

  

AG

None

40

186

0.564

0.80 (0.37–1.73)

−0.22

  

AA

None

147

359

0.258

1.52 (0.73–3.13)

0.42

  

GG

Often

78

123

0.024

2.35 (1.10–4.99)

0.00

0.85

–

AG

Often

113

117

< 0.001

3.57 (1.70–7.53)

−0.22

1.27

−5.54

AA

Often

798

586

< 0.001

5.04 (2.49–10.21)

0.42

1.62

3.85

Alcohol

GG

None

24

19

  

0.00

  

AG

None

45

200

< 0.001

0.18 (0.09–0.35)

−1.73

  

AA

None

136

429

< 0.001

0.25 (0.13–0.47)

−1.38

  

GG

Often

64

141

0.002

0.36 (0.18–0.70)

0.00

−1.02

–

AG

Often

108

103

0.580

0.83 (0.43–1.61)

−1.73

−0.19

0.09

AA

Often

385

516

0.091

0.59 (0.32–1.09)

−1.38

− 0.53

0.30

Fruit intake, > 1 serving/day

GG

Yes

36

96

  

0.00

  

AG

Yes

73

135

0.132

1.44 (0.89, 2.32)

0.36

  

AA

Yes

220

590

0.979

0.99 (0.66, 1.50)

−0.01

  

GG

No

52

64

0.004

2.17 (1.28, 3.68)

0.00

0.77

–

AG

No

80

168

0.315

1.27 (0.80, 2.02)

0.36

0.24

0.66

AA

No

301

355

< 0.001

2.26 (1.50, 3.42)

−0.01

0.82

−81.58

Vegetable intake, > 1 serving/day

GG

Yes

23

117

  

0.00

  

AG

Yes

147

251

< 0.001

2.98 (1.82–4.87)

1.09

  

AA

Yes

311

622

< 0.001

2.54 (1.59–4.06)

0.93

  

GG

No

65

43

< 0.001

7.69 (4.26–13.87)

0.00

2.04

–

AG

No

6

52

0.271

0.59 (0.23–1.53)

1.09

−0.53

−0.49

AA

No

210

323

< 0.001

3.31 (2.05–5.34)

0.93

1.20

1.29

Foods or beverages temperature

GG

Warm

18

60

  

0.00

  

AG

Warm

65

102

0.015

2.12 (1.15–3.92)

0.75

  

AA

Warm

185

462

0.305

1.33 (0.77–2.32)

0.29

  

GG

Hot

70

100

0.006

2.33 (1.27–4.29)

0.00

0.85

–

AG

Hot

88

201

0.202

1.46 (0.81–2.62)

0.75

0.38

0.50

AA

Hot

336

483

0.002

2.32 (1.34–4.00)

0.29

0.84

2.90

Smoked or pickled foods intake

GG

None

35

48

  

0.00

  

AG

None

31

87

0.018

0.49 (0.27–0.89)

−0.72

  

AA

None

229

467

0.092

0.67 (0.42–1.07)

−0.40

  

GG

Often

53

112

0.119

0.65 (0.38–1.12)

0.00

−0.43

–

AG

Often

122

216

0.305

0.77 (0.48–1.26)

−0.72

− 0.26

0.35

AA

Often

292

478

0.450

0.84 (0.53–1.33)

−0.40

−0.18

0.44

  1. *: The interaction coefficient (i.e. γ) was the result of βeg divided by βe. In case of γ > 1, genetic factors amplified the effect of environmental exposures; in case of γ > 1, genetic factors weakened the effect of environmental exposures; in case of γ = 1, no interaction was present between genetic factors and environmental exposures. When the environmental exposure was detrimental, genetic factors were deemed to be strongly protective in case of βe > 0 and γ < 0. The bold results indicated there is a statistically significance when its p value <0.05