Clinical feature | Genotype | Classifications | Case | Control | P value | OR (95% CI) | βe | βeg | γ value* |
---|---|---|---|---|---|---|---|---|---|
Age (years) | GG | <50 | 64 | 130 | Â | Â | 0.00 | Â | Â |
AG | <50 | 35 | 46 | 0.108 | 1.55 (0.91–2.63) | 0.44 |  |  | |
AA | <50 | 240 | 497 | 0.911 | 0.98 (0.70–1.37) | −0.02 |  |  | |
GG | ≥50 | 24 | 30 | 0.120 | 1.63 (0.88–3.00) | 0.00 | 0.49 | – | |
AG | ≥50 | 118 | 257 | 0.712 | 0.93 (0.64–1.35) | 0.44 | −0.07 | −0.16 | |
AA | ≥50 | 281 | 448 | 0.155 | 1.27 (0.91–1.78) | −0.02 | 0.24 | −12.11 | |
Gender | GG | Female | 42 | 34 | Â | Â | 0.00 | Â | Â |
AG | Female | 46 | 92 | 0.002 | 0.40 (0.23–0.72) | −0.90 |  |  | |
AA | Female | 101 | 175 | 0.003 | 0.47 (0.28–0.78) | −0.76 |  |  | |
GG | Male | 46 | 126 | < 0.001 | 0.30 (0.17–0.52) | 0.00 | −1.22 | – | |
AG | Male | 107 | 211 | < 0.001 | 0.41 (0.25–0.68) | −0.90 | −0.89 | 1.00 | |
AA | Male | 420 | 770 | < 0.001 | 0.44 (0.28–0.70) | −0.76 | − 0.82 | 1.08 | |
Smoking | GG | None | 10 | 37 | Â | Â | 0.00 | Â | Â |
AG | None | 40 | 186 | 0.564 | 0.80 (0.37–1.73) | −0.22 |  |  | |
AA | None | 147 | 359 | 0.258 | 1.52 (0.73–3.13) | 0.42 |  |  | |
GG | Often | 78 | 123 | 0.024 | 2.35 (1.10–4.99) | 0.00 | 0.85 | – | |
AG | Often | 113 | 117 | < 0.001 | 3.57 (1.70–7.53) | −0.22 | 1.27 | −5.54 | |
AA | Often | 798 | 586 | < 0.001 | 5.04 (2.49–10.21) | 0.42 | 1.62 | 3.85 | |
Alcohol | GG | None | 24 | 19 | Â | Â | 0.00 | Â | Â |
AG | None | 45 | 200 | < 0.001 | 0.18 (0.09–0.35) | −1.73 |  |  | |
AA | None | 136 | 429 | < 0.001 | 0.25 (0.13–0.47) | −1.38 |  |  | |
GG | Often | 64 | 141 | 0.002 | 0.36 (0.18–0.70) | 0.00 | −1.02 | – | |
AG | Often | 108 | 103 | 0.580 | 0.83 (0.43–1.61) | −1.73 | −0.19 | 0.09 | |
AA | Often | 385 | 516 | 0.091 | 0.59 (0.32–1.09) | −1.38 | − 0.53 | 0.30 | |
Fruit intake, > 1 serving/day | GG | Yes | 36 | 96 |  |  | 0.00 |  |  |
AG | Yes | 73 | 135 | 0.132 | 1.44 (0.89, 2.32) | 0.36 | Â | Â | |
AA | Yes | 220 | 590 | 0.979 | 0.99 (0.66, 1.50) | −0.01 |  |  | |
GG | No | 52 | 64 | 0.004 | 2.17 (1.28, 3.68) | 0.00 | 0.77 | – | |
AG | No | 80 | 168 | 0.315 | 1.27 (0.80, 2.02) | 0.36 | 0.24 | 0.66 | |
AA | No | 301 | 355 | < 0.001 | 2.26 (1.50, 3.42) | −0.01 | 0.82 | −81.58 | |
Vegetable intake, > 1 serving/day | GG | Yes | 23 | 117 |  |  | 0.00 |  |  |
AG | Yes | 147 | 251 | < 0.001 | 2.98 (1.82–4.87) | 1.09 |  |  | |
AA | Yes | 311 | 622 | < 0.001 | 2.54 (1.59–4.06) | 0.93 |  |  | |
GG | No | 65 | 43 | < 0.001 | 7.69 (4.26–13.87) | 0.00 | 2.04 | – | |
AG | No | 6 | 52 | 0.271 | 0.59 (0.23–1.53) | 1.09 | −0.53 | −0.49 | |
AA | No | 210 | 323 | < 0.001 | 3.31 (2.05–5.34) | 0.93 | 1.20 | 1.29 | |
Foods or beverages temperature | GG | Warm | 18 | 60 | Â | Â | 0.00 | Â | Â |
AG | Warm | 65 | 102 | 0.015 | 2.12 (1.15–3.92) | 0.75 |  |  | |
AA | Warm | 185 | 462 | 0.305 | 1.33 (0.77–2.32) | 0.29 |  |  | |
GG | Hot | 70 | 100 | 0.006 | 2.33 (1.27–4.29) | 0.00 | 0.85 | – | |
AG | Hot | 88 | 201 | 0.202 | 1.46 (0.81–2.62) | 0.75 | 0.38 | 0.50 | |
AA | Hot | 336 | 483 | 0.002 | 2.32 (1.34–4.00) | 0.29 | 0.84 | 2.90 | |
Smoked or pickled foods intake | GG | None | 35 | 48 | Â | Â | 0.00 | Â | Â |
AG | None | 31 | 87 | 0.018 | 0.49 (0.27–0.89) | −0.72 |  |  | |
AA | None | 229 | 467 | 0.092 | 0.67 (0.42–1.07) | −0.40 |  |  | |
GG | Often | 53 | 112 | 0.119 | 0.65 (0.38–1.12) | 0.00 | −0.43 | – | |
AG | Often | 122 | 216 | 0.305 | 0.77 (0.48–1.26) | −0.72 | − 0.26 | 0.35 | |
AA | Often | 292 | 478 | 0.450 | 0.84 (0.53–1.33) | −0.40 | −0.18 | 0.44 |