SNP rs12982687 affects binding capacity of lncRNA UCA1 with miR-873-5p: involvement in smoking-triggered colorectal cancer progression

Table 2 Association of single nucleotide polymorphisms within UCA1 with the risk of colorectal cancer

Gene	rs number	Allele Change	Mode	Genotype	CRC	Control	P value	OR (95% CI)^*
LncRNA UCA1	rs11085996	A > G	Allelic model	A	1195	2193		1
			Allelic model	G	329	623	0.684	0.97 (0.83–1.13)
			Dominant model	AA	521	945		1
			Dominant model	AG + GG	241	463	0.213	0.88 (0.71–1.08)^a
			Recessive model	AA+AG	674	1248		1
			Recessive model	GG	88	160	0.026	0.84 (0.72–0.98)^a
	rs12982687	C > T	Allelic model	C	1188	2065		1
			Allelic model	T	336	751	0.001	0.78 (0.67–0.90)
			Dominant model	CC	463	751		1
			Dominant model	CT + TT	299	657	0.025	0.78 (0.62–0.97)^a
			Recessive model	CC + CT	725	1314		1
			Recessive model	TT	37	94	0.917	0.98 (0.64–1.50) ^a

*OR (Allelic model) = Mutant allele/Wild allele, OR (Dominant model) = (Heterozygote+Mutant homozygote)/Wild homozygote, OR (Recessive model) = Mutant homozygote/(Wild homozygote+Heterozygote), ^a Gender, smoking, alcohol, fruit intake, vegetable intake, food/beverage temperature and smoked food adjusted OR. The bold results indicated there is a statistically significance when its p value <0.05

ISSN: 1478-811X