Fig. 7From: Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin levelModel of NAMPT’s role in the proliferation of human CRC cells through the regulation of Wnt/β-catenin signaling. A high level of NAMPT (left panel) yields more NAD+ and induces downregulation of Axin and the nuclear translocation of β-catenin, thereby leading to the activation of Wnt/β-catenin signaling and the increased growth of CRC cells. However, when NAMPT is inhibited by genetic or pharmacological methods (right panel), the NAD+ level is reduced and Axin is upregulated. Then, β-catenin is degraded, and the Wnt/β-catenin pathway is suppressed, resulting in the inhibition of cancer cell proliferationBack to article page