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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level

Fig. 6

Knockdown of NAMPT suppresses CRC cell growth in vivo. a-d The effect of NAMPT expression on in vivo tumorigenicity was evaluated using a xenograft nude mouse model. a Tumors formed in nude mice; b dissected subcutaneous tumors, scale bars: 10 mm; c curves of tumor growth; d tumor weight; number = five mice/group. The error bars indicate the SD. Student’s t-test was used for statistical analysis. e The protein expression levels of NAMPT in xenograft tumors were analyzed by western blotting. f Quantification of the protein expression levels of NAMPT in xenograft tumors. Student’s t-test was used for statistical analysis. g Representative images of IHC staining for NAMPT in the xenografts. The box graphs show the quantification of IHC staining. Scale bars: 50 μm. Student’s t-test was used for statistical analysis. * P < 0.05, ** P < 0.01, and *** P < 0.001 compared with the control group

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Cell Communication and Signaling

ISSN: 1478-811X