Cell Communication and Signaling

Table 4 Correlations between ARC and p53, COX-2, Bcl-2, nuclear β-catenin and MMR proteins (statistically significant results in bold type)

From: Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin

		ARC (cytoplasmic)	ARC (nuclear)
MLH1	Spearman correlation	− 0.028	0.074
	Significance (two-sided)	0.687	0.288
	n	207	207
MSH2	Spearman correlation	0.021	0.034
	Significance (two-sided)	0.763	0.624
	n	206	206
MSH6	Spearman correlation	− 0.004	0.071
	Significance (two-sided)	0.958	0.313
	n	205	205
P53 (score 2)	Spearman correlation	0.109	0.175^*
	Significance (two-sided)	0.120	0.012
	n	204	204
Bcl-2	Spearman correlation	0.267^**	0.142^*
	Significance (two-sided)	0.001	0.045
	n	200	200
COX-2	Spearman correlation	0.066	0.149^*
	Significance (two-sided)	0.357	0.036
	n	198	198
Nuclear β-catenin	Spearman correlation	0.019	0.249**
	Significance (two-sided)	0.780	0.001
	n	207	207

Nuclear ARC expression was found to correlate significantly (p < 0.05*) with the expression of Bcl-2, COX-2, with strong p53 expression and with nuclear β-catenin. In contrast, expression of cytoplasmic ARC only correlated with Bcl-2 but with none of other proteins; however, this correlation was highly significant (p < 0.01**)

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ISSN: 1478-811X

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