Skip to main content
Fig. 3 | Cell Communication and Signaling

Fig. 3

From: mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy

Fig. 3

Hyperglycemia-induced molecular events and consequences in STZ mice retina. a The expression of mTOR related proteins, GLUT1 and β-actin detected by Western blot. b Relative expression of the pS6 ribosomal protein and GLUT1 normalized to β-actin. c Cryosections of the mouse retina immunostained for cleaved caspase 3 (green) and NeuN (red), GCL—ganglion cell layer; Scale bar: 50 µm. d Cleaved caspase 3 positive cell number in the GCL of the normal and diabetic mouse retina (n = 6/group). e Total cell number and NeuN positive cell number (normalized to the Hoechst nuclear counterstain) in the GCL of the normal and diabetic mouse retina. (n = 6/group). #p ≤ 0.05, compared with the Normal and 1mDM group; *p ≤ 0.05

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X