Table 2 Top downregulated genes in D7 TCQA-treated hAECs (vs D7 control) *
Gene symbol | Gene name | Biological function | Fold-change | P value** |
|---|---|---|---|---|
TNFα | Tumor necrosis factor alpha | Inflammatory response; Cell activation; Cell death; Negative regulation of apoptotic process |  − 3.65 | 0.004 |
IL6 | Interleukin 6 | Negative regulation of collagen biosynthesis; Inflammatory response; Cytokine response |  − 3.32 | 0.009 |
IL8 | Interleukin 8 | Pro-inflammatory response; Angiogenesis; Phagocytose |  − 2.88 | 0.016 |
FOS | FBJ osteosarcoma oncogene | Cyclin D1 activation; Cell cycle regulation |  − 2.80 | 0.001 |
ABCG1 | ATP-binding cassette transporter G1 | Cholesterol accumulation; T cell homeostasis alteration |  − 2.65 | 0.045 |
PTGS2 | Prostaglandin G/H synthase 2 | Production of inflammatory prostaglandins; Cell adhesion; Resistance to apoptosis; Tumor angiogenesis |  − 2.65 | 0.033 |
SORT1 | Sortilin | Neuronal apoptosis: Coronary artery disease; Tumor cell survival |  − 2.45 | 0.012 |
GPNMB | Glycoprotein non-metastatic melanoma protein B | Alzheimer disease marker; Regulator of melanoma tumor growth |  − 2.43 | 0.004 |
IRF2 | Interferon regulatory factor 2 | Oncogene; Human leukaemia cell growth |  − 2.24 | 0.001 |
KLK6 | Kallikrein-6 | Pathogenesis of Parkinson disease; Collagen and filament degradation |  − 2.22 | 0.023 |
TRPV3 | Transient receptor potential cation channel subfamily V member 3 | Negative regulator of hair growth and cycling; Suppresses keratinocyte proliferation |  − 2.17 | 0.043 |
IFNLR1 | Interferon, lambda receptor 1 | Inflammatory and cytokine response |  − 2.12 | 0.002 |