Fig. 3
From: Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling
Schematic diagram depicting IL17RD (Sef) regulation of the IL17 signaling cascade and associated disease relevance. IL17RD binds to IL17RA in a cell type dependent manner to regulate IL-17 signaling. Upon binding of IL17A to the IL17RA/IL17RC/IL17RD receptor complex, IL17RD modulates the recruitment of adapter proteins ACT1 and TRAF6 to the receptor complex. IL17RD subsequently regulates the polyubiquitination of TRAF6; as well as the activation of predominantly the p38 MAPK, and the ERK, JNK and NF-κB pathways to differentially regulate expression of target genes. Consequently, genetic perturbations and disruptions in IL17RD expression have been associated with several inflammatory diseases and immunomodulatory phenotypes associated with the IL17 signaling superfamily