Fig. 1From: Immuno-oncology: are TAM receptors in glioblastoma friends or foes?The structural features of TAM receptors and their ligands. TAM receptors have a unique intracellular protein tyrosine kinase domain (named KW(I/L)A(I/L)ES) that distinguishes them from other RTKs. TAM receptors use their extracellular N-terminal immunoglobulin-like domains to bind laminin G (LG) domains of TAM ligands. Gas6 and ProS are the most well-known soluble circulating proteins ligands for TAM receptors, which own a similar N-terminal gamma-carboxyglutamic acid domain structure. TAM receptors, Tyro3, Axl and Mertk receptors; RTKs, receptor tyrosine kinases; Gas6, growth arrest-specific 6; ProS, protein S; FNIII, fibronectin type-III domains. LG domains, laminin G domains; EGF-like domains, epidermal growth factor-like domainsBack to article page