Fig. 1
From: Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism
Basic expression level for the four cells types under standard culture conditions derived from RT-qPCR data (n = 3). a The relative expression level of cytokines and chemokines in the investigated cell types. Except for two highly significantly upregulated markers in stem cells (IL-1β and IL-8), these signalling molecules exhibit no significant tendency between samples or cell types. b The relative expression of growth factors for all cell types. Again a slight but significant upregulation in fibroblasts can be detected for IGF-2. Besides that, cholesteatoma cells exhibit a significantly higher expression of KGF and IGF-2. (Depicted: mean and standard deviation of mean; *≤ 0.05, **≤ 0.01, ****≤ 0.0001, on tailed ration paired t-test, 95% confidence interval upon passed Shapiro–Wilk normality test)