Fig. 3From: Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunitiesASC/PYCARD PTMs and the enzymes responsible for their regulation. Empirically validated enzymes which are responsible for the PTM regulation of ASC/PYCARD. “+” indicates that the enzyme promotes the activation of ASC oligomerization, while “−” indicates repression of its function. Amino acid residues shown above refer to human ASC, those in brackets refer to mouse ASC residuesBack to article page