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Table 1 Lateral diffusion characteristics of Gα subunits in HEK293 cells in the presence of Gβ1γ2 and/or dopamine D2 receptor

From: The Gαi protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane

 

Dapp

(µm2 s−1)

Mf

(%)

N

Gαsa

0.130 ± 0.004

84.5 ± 1.5

49

Gαs Gβ1γ2b

0.246 ± 0.009

92.4 ± 0.8

143

Gαs D2R

0.232 ± 0.009

89.0 ± 1.0

88

Gαsβ1γ2 D2R

0.245 ± 0.009

90.6 ± 1.1

110

Gαi1

0.316 ± 0.012

91.8 ± 1.4

55

Gαi11γ2

0.237 ± 0.010

88.2 ± 1.6

53

Gαi1 D2R

0.356 ± 0.014

92.2 ± 1.4

45

Gαi1β1γ2 D2R

0.291 ± 0.012

91.0 ± 1.2

60

Gαi2

0.474 ± 0.015

95.2 ± 0.7

120

Gαi21γ2

0.526 ± 0.019

94.1 ± 1.3

50

Gαi2 D2R

0.467 ± 0.020

93.1 ± 1.4

58

Gαi2β1γ2 D2R

0.345 ± 0.013

90.9 ± 1.3

60

Gαi3a

0.338 ± 0.022

94.2 ± 1.7

34

Gαi31γ2b

0.424 ± 0.014

93.5 ± 0.9

66

Gαi3 D2R

0.358 ± 0.016

90.1 ± 1.5

60

Gαi3β1γ2 D2R

0.381 ± 0.014

91.0 ± 1.4

50

  1. In the experiments where the co-expression took place, the diffusion of Gα subunits was measured. Values represent the mean ± S.E.M
  2. Dapp—apparent diffusion coefficient, Mf—mobile fraction
  3. aData from Ref. [40]
  4. bData from Ref. [34]