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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: TNFα priming through its interaction with TNFR2 enhances endothelial progenitor cell immunosuppressive effect: new hope for their widespread clinical application

Fig. 3

Hypothetic interaction between ECFCs and T cells. a This schematic depicts the involvement of TNFα-TNFR2 axis in immunosuppressive effect of ECFCs on T cells. Briefly, T cells upon activation produce pro-inflammatory cytokines including TNFα. This cytokine through its interaction with TNFR2 mediates ECFC immunosuppressive function. b This schematic depicts our hypothesis based on the priming effect of TNFα treatment on ECFC immunosuppressive effect. Briefly, pre-treating ECFCs with proper dose of TNFα could increase the expression of TNFR2 which in turn boosts ECFCs toward enhanced immunosuppressive and immunomodulatory functions

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Cell Communication and Signaling

ISSN: 1478-811X